Beginners Corner
- Skill unlocks:
- Druidic Ritual — Unlocks Herblore and the ability to use lamps and books of knowledge on Herblore
- Rune Mysteries — Unlocks the ability to use lamps and books of knowledge on Runecraft
- Tears of Guthix — Unlocks weekly access to a minigame that rewards experience in the player's lowest skill, which is useful in aiding progress towards skilling goals
- Desert Treasure I — Unlocks the ability to use Ancient Magicks
- A Kingdom Divided — Unlocks 24 Arceuus spells: combat spells with the exception of Ghostly Grasp and Inferior Demonbane, and utility spells with the exception of Resurrect Crops and reanimation spells
- Lunar Diplomacy — Unlocks the ability to use Lunar spellbook
- Dream Mentor — Unlocks the Lunar spells: Monster Examine, Humidify, Hunter Kit, Stat Spy, Dream, Plank Make, Spellbook Swap
- King's Ransom — Unlocks Chivalry and Piety prayers
- Area unlocks
- Children of the Sun – Unlocks Varlamore
- Priest In Peril – Unlocks Morytania
- Bone Voyage – Unlocks Fossil Island
- Throne of Miscellania – Unlocks Managing Miscellania
- Regicide – Unlocks Tirannwn
- Mourning's End Part I – Unlocks Lletya
- Song of the Elves – Unlocks Prifddinas
- Making Friends with My Arm – Unlocks Weiss
- Sins of the Father – Unlocks Darkmeyer
- Cabin Fever - Unlocks Mos Le'Harmless
- Perilous Moons - Unlocks Cam Torum and Neypotzli
- The Heart of Darkness - Unlocks Ruins of Tapoyauik
- Transportation unlocks:
- Plague City – Unlocks Ardougne Teleport (Tablet teleport and spellbook teleport)
- Enlightened Journey – Unlocks the balloon transport system
- Fairytales Part 1 and start Part 2 – Access to fairy rings
- Tree Gnome Village – Unlock spirit tree teleports
- The Grand Tree – Unlocks gnome glider transportation
- Ghosts Ahoy – Unlocks Ectophial and free passage to Port Phasmatys
- Watchtower – Unlocks Watchtower Teleport (Tablet teleport and spellbook teleport)
- A Taste of Hope – Unlocks Drakan's medallion
- Eadgar's Ruse – Unlocks Trollheim teleport
- Shilo Village – Unlocks Shilo Village cart system
- Client of Kourend – Unlocks Kourend Castle Teleport (Tablet teleport and spellbook teleport)
- Twilight's Promise – Unlocks the Quetzal Transport System
- Equipment unlocks:
- The Great Brain Robbery – Unlocks the barrelchest anchor
- Dwarf Cannon – Unlocks the dwarf multicannon
- Dragon Slayer I – Ability to use green d'hide body and rune platebody
- Dragon Slayer II – Ability to create Ava's assembler
- Family Crest – Unlocks steel gauntlets
- Animal Magnetism – Unlocks Ava's device
- The Slug Menace – Unlocks proselyte armour
- Recipe for Disaster – Completion of the subquests unlocks better Culinaromancer's gloves
- Lost City – Ability to use the dragon dagger and the dragon longsword
- A Taste of Hope – Unlocks Ivandis flail
- Monkey Madness I – Ability to use dragon scimitar
- Monkey Madness II – Ability to use the heavy ballista
- The Fremennik Isles – Unlocks helm of Neitiznot
- The Fremennik Exiles – Unlocks Neitiznot faceguard
- Haunted Mine – Unlocks salve amulet
- Beneath Cursed Sands – Unlocks Keris partisan